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How common is covid-19 in children?   Since the outbreak of sars-cov-2 viral infection children are found to less susceptible to infection. Very few cases require ICU care. However, recently few cases with significant inflammatory findings resembling Kawasaki disease (KD) or KD shock have been reported. What is multisystem inflammatory syndrome in children (MIS-C)?   It is a rare condition in children with covis-19 presenting with features like Kawasaki disease. They have been found to have features of cytokine storm. Also called Pediatric multisystem inflammatory syndrome (PMIS) Pediatric inflammatory multisystem syndrome (PIMS) Pediatric hyperinflammatory syndrome or shock. This KD like illness was first reported from United Kingdom in mid-April. There was a case series published from Italy as well. However, after that many cases have been reported from other European countries, USA (particularly New York) and Canada. Although it is a rare presentation, pediatrician

As we now know that the high viral load in the beginning followed by exaggerated immune response later is responsible for severe covid-19. This leads to ARDS- primary cause of death, along with multiple organ dysfunction. The understanding of the cytokine storm provides key information regarding key theoretical therapeutic interventions. These therapeutic interventions that can suppress the excess immune response through various mechanisms. Today I will discuss about few such pharmacological agents. CLICK HERE FOR DETAILS ON CYTOKINE STORM The pathogenesis and treatment of the ‘Cytokine Storm’ in COVID-19Q. Ye, B. Wang and J. Mao / Journal of Infection 80 (2020) 607–613   IFN-gamma Use – Can stimulate alveolar epithelial cells for their action against virus by stimulating certain antiviral genes It can inhibit IFN- α/β secretion and inhibit excess activation of macrophage-monocyte. It can inhibit excess neutrophils Disadvantages Should be used in early in the disease co