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Showing posts from July, 2020

Journal article- Single-Dose Nirsevimab for Prevention of RSV in Preterm Infants

Single-Dose Nirsevimab for Prevention of RSV in Preterm Infants Source: NEJM, Published July 30,2020 Respiratory syncytial virus is the most common cause of lower respiratory tract infection and one of the major cause of hospitalization in children. Palivizumab   and ribavirin are the only therapeutic options for the disease caused by this virus. However,  P alivizumab  isn't recommended for evey children and the efficacy of Ribavirin is not good. Nirsevimab, a recombinant human immune globulin G1 kappa monoclonal antibody  which was the drug under study and the outcome has been presented in this article. What was the methodology? This trial was conducted in both northern and southern hemispheres. Nirsevimab was evaluated for the prevention of RSV-associated lower respiratory tract infection in healthy infants who had been born preterm (29 weeks 0 days to 34 weeks 6 days of gestation).  Infants were assigned in a 2:1 ratio to receive nirsevimab, at a dose of 50 mg in a single intra


What is DKA as per ISPAD?    The biochemical criteria for the diagnosis of diabetic ketoacidosis (DKA) are: • Hyperglycemia (blood glucose:11 mmol/L [≈200 mg/dL]) • Venous pH;7.3 or serum bicarbonate :15 mmol/L • Ketonemia (blood ß-hydroxybuyrate ≥3 mmol/L) or moderate or large   ketonuria       What is DKA as per BSPED?     Diagnose DKA in children and young people who have Acidosis (indicated by blood pH below 7.3 or plasma bicarbonate below 15 mmol/litre) and ketonaemia (indicated by blood beta-hydroxybutyrate above 3 mmol/litre). What are mild, moderate & severe DKA?           When is insulin started in DKA management? 1 hour after starting fluid resuscitation       What is the most common cause of DKA in new case of DM?       Delay in diagnosis Low socioeconomic status Residence in a country with a low prevalence of type 1 (T1DM). What is hyperglycemic hyperosmolar state? • Plasma glucose concentration 33.3 mmol/L (600 mg/dL) • Venous pH: