a2zmedicalnote

  Parts of DNA Phosphate group + sugar + Base (nitrogenous base) Difference between sugar of DNA and RNA DNA has deoxyribose sugar(1 OH group attached to sugar and RNA has ribose sugar (2 OH groups) Nucleotide and nucleoside Nucleotide = Phosphate group + Base + sugar Nucleoside = Base and sugar Types of Nitrogenous base Purines and Pyrimidines Purines consists of Pure As Gold = Adenine and Guanine Pyrimidine consists of CUT the pyramids Cytosine Uracil (only in RNA) Thymine Purine nucleosides are Adenosine and Guanosine Pyrimidine nucleosides are Cytidine, Uridine and Thymidine Purine nucleotides Adenosine monophosphate, Guanosine MP How is DNA packed inside nucleus ? In the form of chromatin which is further condensed to form chromosomes What is a nucleosome ? DNA coiled twice around an octamer of Histone composed of (H2A, H2B, H3, H4) x2 with linker H1 protein. Positive and Negative charge of Chromatin Positive charged =  Lysine  and  Arginine  of Histone whi...

In 1841, the general practitioner W.J. West from Tunbridge wrote a letter to the editor of Lancet entitled “On a peculiar form of infantile convulsions.” West’s goal was to draw the attention of his colleagues to “a very rare and singular species of convulsions peculiar to young children.” He described his son’s symptoms in detail, in a letter conveying both the objectivity of the physician and the frustrations of a father with a severely ill child. This description includes all of the features of the entity currently called “infantile spasms” The term Infantile spasms syndrome defines an epileptic syndrome occurring in children younger than 1 year (rarely older than 2 years), with clinical spasms usually occurring in clusters whose most characteristic EEG finding is hypsarrhythmia [the spasms are often associated with developmental arrest or regression]. Some definitions: West syndrome: Combination of spasms in clusters and an EEG pattern of hypsarrhythmia and delayed brain developmen...