1. What are the clinical features of congenital hypothyroidism in a newborn? The clinical manifestations are commonly subtle in newborns with congenital hypothyroidism (CH). Newborns with CH may be asymptomatic because of presence of maternal T 4 (which contributes to approximately one-third of circulating T 4 in a newborn) and residual functioning thyroid tissue. FEATURES AT BIRTH The classical symptoms of congenital hypothyroidism include · lethargy, · hoarse cry, · feeding difficulty, · constipation not responding to treatment, and increased somnolence. The characteristic signs of CH include · Prolonged neonatal jaundice, · Macroglossia, · Umbilical hernia, · Wide posterior fontanelle, · Hypotonia, · Dry skin, · Head circumference may be slightly increased d/t myxedema of brain · Hypothermia. · Hirsute for
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